Patch Test Analysis of Channa Striata Extract Biopolymer

Dina A Dalimunthe; Flora Marita Lubis; Cut Putri Hazlianda; Riana Miranda Sinaga; Jesryn Dhillon; Patricia Hutagalung; Guntur Berlian

doi:10.71197/jsocmed.v4i6.217

Patch Test Analysis of Channa Striata Extract Biopolymer

Dina A Dalimunthe
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Flora Marita Lubis
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Cut Putri Hazlianda
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Riana Miranda Sinaga
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Jesryn Dhillon
Resident of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Patricia Hutagalung
Resident of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Guntur Berlian
Farmacology Department, Scientific Affairs Division of Mega Medica Pharmaceuticals, Indonesia

Abstract

Introduction: Wound healing involves complex interactions between cells and mediators that occur immediately after the wound occurs and depends on nutritional factors and wound closure. Snakehead murrel fish (Channa striata) extract has been extensively researched to speed up the wound healing process because of its high amino acid content. Patch tests were carried out to assess the allergen potential of the Channa striata extract biopolymer in the form of wound dressings.

Methods: Experimental study of 40 subjects who had admit patch test with various consentration of Channa striata extract biopolymer. The patch test materials divided of 5 grups. They were aquadest solution, Eucheuma cottonii biopolymer, Channa striata extract biopolymer concentrations of 5.4 g/mL, 10.8 g/mL, and 21.6 g/mL. All subjects had been assessed for skin reactions that occured after 48 hours, 72 hours, and 96 hours.

Results: A total of 40 subjects met the inclusion criteria and completed informed consent. There was minimum allergen reaction (+) in slight subject in all grups except aquadest grup after 48 hours. The allergic reaction dissolve in 72 and 96 hours. An irritant reaction (IR) occurred in among all grups but indicated to the hypafix plaster.

Conclusion: Patch test containing biopolymer Channa striata extract showed a minimal allergic reaction

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Published at

30. June 2025
https://doi.org/10.71197/jsocmed.v4i6.217
Issue:

Vol. 4 No. 6 (2025): June
Section:

Articles
Keywords:

Patch test Channa striata extract Allergic reaction Wound healing
References:

Musa AF, Dillion J, Mohd Taib ME, Mohd Yunos A, Baie S, Bin Nordin R. Effect of Haruan fish extract (Channa striatus) on wound healing and quality of life in patients after coronary artery bypass grafting (CABG) patients: A prospective, double-blind, randomized, controlled trial. F1000Res. 2018; 7:469.

Hadisaputro S, Sunarjo L. Effectiveness of Hydrogel from Snakehead Fish Extract (Channa Striata) on Wound Healing of Grade II Ulcer in Patients with Type II Diabetes Mellitus 2021; 4:8.

Issains FB, Trinanda AF, Basyir AM, Benaya A, Yuwono AH, Ramahdita G. Extraction of collagen Type-I from snakehead fish skin (Channa striata) and synthesis of biopolymer for wound dressing. Presented at the 4th Biomedical Engineering’s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019, Padang, Indonesia, 2019. p. 020013.

Aderibigbe B, Buyana B. Alginate in wound dressings. Pharmaceutics. 2018; 10:42.

Laila L, Febriyenti F, Salhimi SM, Baie S. Wound healing effect of Haruan (Channa striatus) spray. Int Wound J. 2011; 8:484–491.

Setiawan MR, Dewi N, Oktaviyanti IK. Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka. Haruan (Channa striata) extract increases neocapillary count during wound healing. Journal of Dentomaxillofacial Sciences. 2015; 1: 1-5.

Sura GM, Carabelly AN. Haruan extract (Channa striata) 100% was applied to wounds on the back of mice (Mus musculus) and the number of neutrophils and macrophages was determined. Tesis. 2013.

Ab Wahab SZ, Abdul Kadir A, Nik Hussain NH, Omar J, Yunus R, Baie S, Mohd Noor N, Hassan II, Wan Mahmood WH, Abd Razak A, Wan Yusoff WZ. Effect of Channa striatus (Haruan) Extract on Pain and Wound Healing in Women after Lower Segment Caesarean Section Evid Based Complement Alternat Med. 2015:1–6.

Baie SH, Sheikh KA. Wound healing properties of Channa striatus-cetrimide cream—tensile strength measurement. J Ethnopharmacol. 2000; 71:93–100.

Daisa F, Andrie M, Taurina W. The effectiveness of an oil phase ointment containing Channa striata (snakehead fish) extract was tested on open stage II acute wounds in Wistar strain male rats. Trad Med J. 2017; 22:97.

Nixon RL, Mowad CM, Marks Jr. JG. Pigmentation disorders. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4th ed. London: Mosby; 2018. p. 242–261.

Svedman C, Bruze M. Patch testing: Technical details and interpretation. In: Johansen JD, et al., editors. Contact Dermatitis. 6th ed. Germany: Springer; 2020. p. 515–540.

Turrentine, JE, Sheehan, M. P., Allergic contact dermatitis. In: Kang S, et al., editors. Fitzpatrick’s Dermatology in General Medicine. 9th ed. New York: McGraw-Hill; 2019. p. 395–391.

Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, Cannavó A, Giménez-Arnau A, Gonçalo M, Goossens A, John SM, Lidén C, Lindberg M, Mahler V, Matura M, Rustemeyer T, Serup J, Spiewak R, Thyssen JP, Vigan M, White IR, Wilkinson M, Uter W. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice: Escd Patch Test Guideline. Contact Dermatitis. 2015; 73:195–221.

Spencer A, Gazzani P, Thompson DA. Acrylate and methacrylate contact allergy and allergic contact disease: A 13-year review. (Meth)Acrylate Contact Allergy And Allergic Contact Disease. Contact Dermatitis. 2016;75(3):157–164.

Aasmoe L, Bang B, Andorsen GS, Evans R, Gram IT, Lochen ML. Skin symptoms in the seafood-processing industry in northern Norway. Contact Dermatitis. 2005;52(2):102–107.

James CA, Welham S, Rose P. Edible algae allergenicity – a short report. J Appl Phycol. 2023; 35:339–352.
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Dalimunthe, D. A., Lubis, F. M., Hazlianda, C. P., Sinaga, R. M., Dhillon, J., Hutagalung, P., & Berlian, G. (2025). Patch Test Analysis of Channa Striata Extract Biopolymer. Journal of Society Medicine, 4(6), 183–187. https://doi.org/10.71197/jsocmed.v4i6.217