Polycystic Ovary Syndrome (PCOS) as a Risk Factor for Preeclampsia and Cognitive Dysfunction

Ira Febri Yani; Irmiya Rachmiyani; Yudhisman Imran; Triasti Khusfiani; Dina Putri Nasution; Emad Yousif

doi:10.71197/jsocmed.v5i5.302

Polycystic Ovary Syndrome (PCOS) as a Risk Factor for Preeclampsia and Cognitive Dysfunction

Ira Febri Yani
Department of Obstetrics and Gynecology, Hermina Hospital, Tangerang, Indonesia
Irmiya Rachmiyani
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Yudhisman Imran
Department of Neurology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Triasti Khusfiani
Department of Pharmacology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Dina Putri Nasution
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Emad Yousif
Department of Chemistry, Al-Nahrain University, Baghdad, Iraq

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is associated with various metabolic disturbances, such as insulin resistance, obesity, dyslipidemia, and chronic inflammation, which may increase the risk of pregnancy complications, such as preeclampsia. In addition to increasing the risk of preeclampsia, PCOS has also been linked to a decline in cognitive function resulting from the effects of hyperandrogenism, insulin resistance, and systemic inflammation on neuronal function. Therefore, PCOS not only increases the risk of developing preeclampsia but may also play an indirect role in cognitive dysfunction. This narrative review discusses the role of PCOS as a risk factor for preeclampsia and cognitive impairment and the interconnected pathophysiological mechanisms linking these conditions.

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Published at

31. May 2026
https://doi.org/10.71197/jsocmed.v5i5.302
Issue:

Vol. 5 No. 5 (2026): May
Section:

Original Research
Keywords:

Polycystic Ovary Syndrome (PCOS) Preeclampsia Cognitive Function
References:

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Yani, I. F., Rachmiyani, I., Imran, Y., Khusfiani, T., Nasution, D. P., & Yousif, E. (2026). Polycystic Ovary Syndrome (PCOS) as a Risk Factor for Preeclampsia and Cognitive Dysfunction. Journal of Society Medicine, 5(5), 194–199. https://doi.org/10.71197/jsocmed.v5i5.302