Patch Test Analysis of Channa Striata Extract Biopolymer

Dina A Dalimunthe; Flora Marita Lubis; Cut Putri Hazlianda; Riana Miranda Sinaga; Jesryn Dhillon; Patricia Hutagalung; Guntur Berlian

doi:10.71197/jsocmed.v4i6.217

Patch Test Analysis of Channa Striata Extract Biopolymer

Dina A Dalimunthe
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Flora Marita Lubis
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Cut Putri Hazlianda
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Riana Miranda Sinaga
Dermatology and Venerology Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Jesryn Dhillon
Resident of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Patricia Hutagalung
Resident of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Guntur Berlian
Farmacology Department, Scientific Affairs Division of Mega Medica Pharmaceuticals, Indonesia

Abstract

Introduction: Wound healing involves complex interactions between cells and mediators that occur immediately after the wound occurs and depends on nutritional factors and wound closure. Snakehead murrel fish (Channa striata) extract has been extensively researched to speed up the wound healing process because of its high amino acid content. Patch tests were carried out to assess the allergen potential of the Channa striata extract biopolymer in the form of wound dressings.

Methods: Experimental study of 40 subjects who had admit patch test with various consentration of Channa striata extract biopolymer. The patch test materials divided of 5 grups. They were aquadest solution, Eucheuma cottonii biopolymer, Channa striata extract biopolymer concentrations of 5.4 g/mL, 10.8 g/mL, and 21.6 g/mL. All subjects had been assessed for skin reactions that occured after 48 hours, 72 hours, and 96 hours.

Results: A total of 40 subjects met the inclusion criteria and completed informed consent. There was minimum allergen reaction (+) in slight subject in all grups except aquadest grup after 48 hours. The allergic reaction dissolve in 72 and 96 hours. An irritant reaction (IR) occurred in among all grups but indicated to the hypafix plaster.

Conclusion: Patch test containing biopolymer Channa striata extract showed a minimal allergic reaction

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Published at

30. June 2025
https://doi.org/10.71197/jsocmed.v4i6.217
Issue:

Vol. 4 No. 6 (2025): June
Section:

Articles
Keywords:

Patch test Channa striata extract Allergic reaction Wound healing
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Dalimunthe, D. A., Lubis, F. M., Hazlianda, C. P., Sinaga, R. M., Dhillon, J., Hutagalung, P., & Berlian, G. (2025). Patch Test Analysis of Channa Striata Extract Biopolymer. Journal of Society Medicine, 4(6), 183–187. https://doi.org/10.71197/jsocmed.v4i6.217