Antidiabetic Effects of Moringa oleifera Leaf Extract on Blood Glucose Levels in Alloxan-Induced Diabetic Rats (Rattus norvegicus): A Systematic Literature Review
Authors
Abstract
Introduction: This systematic literature review, guided by PRISMA guidelines, evaluates the effectiveness of Moringa oleifera leaf extracts in reducing blood glucose levels in alloxan-induced diabetic rats.
Method: Literature was searched in PubMed and Google Scholar using keywords including “Moringa oleifera,” “leaf extract,” “alloxan-induced diabetes,” and “blood glucose.” From 472 identified articles, 9 studies met inclusion criteria and were analyzed.
Results: Nearly all studies reported significant reductions in blood glucose levels following administration of Moringa oleifera leaf extracts at effective doses ranging from 200–800 mg/kg body weight over 14–28 days. Key mechanisms include protection of pancreatic β-cells from oxidative stress, enhanced insulin secretion, and improved insulin sensitivity. Both aqueous and ethanolic extracts exhibited antihyperglycemic effects, with aqueous extracts demonstrating faster onset and ethanolic extracts providing more sustained outcomes.
Conclusion: These findings support the potential of Moringa oleifera leaf extracts as a natural antidiabetic agent in preclinical models. However, further research is required to standardize extraction methods, dosages, and molecular mechanisms to facilitate clinical translation in humans.
Similar Articles
- Maisyarah Farhati Lubis, Heny Syahrini Lubis, Dairion Gatot , Relationship Between D-Dimer Levels and Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Deep Vein Thrombosis Patients , Journal of Society Medicine: Vol. 4 No. 4 (2025): April
- Suci Asriri Pradina Muslim, Hilfan Ade Putra Lubis , Ali Nafiah Nasution , The Relationship Between Low-Density Lipoprotein Cholesterol and Coronary Artery Calcium Score in Patients with Chronic Coronary Syndrome Without Diabetes Mellitus at RSUP Haji Adam Malik Medan , Journal of Society Medicine: Vol. 4 No. 3 (2025): March
- Defriyan Ramzi, Harris Hasan, Abdul Halim Raynaldo, The Relationship Between Platelet and Lymphocyte Ratios and Left Atrial Thrombus Formation in Patients with Severe Mitral Stenosis due to Rheumatic Heart Disease at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 4 No. 3 (2025): March
- Rikki Oktrian Putra, Yudhisman Imran, Mulia Rahmansyah, Triasti Khusfiani, Mustika Anggiane Putri, Ainaya Az zahra, Case Report of Management of Increased Intracranial Pressure in Epidural Hematoma , Journal of Society Medicine: Vol. 3 No. 3 (2024): March
- Rinda Chindra Risanti, Nelva Karmila Jusuf, Imam Budi Putra, Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma , Journal of Society Medicine: Vol. 3 No. 3 (2024): March
- Ella Finarsih ES, Imam Budi Putra, Meidina Kesuma Wardani, Comparison of Adiponectin Levels in Patients with Familial and Non-Familial Keloid History , Journal of Society Medicine: Vol. 4 No. 1 (2025): January
- Adityo Prabowo, Use of Chest X-Ray (CXR) in Covid-19 Screening as A Modalities , Journal of Society Medicine: Vol. 1 No. 2 (2022): November
- Aziz Achmad, Zainal Safri, Teuku Bob Haykal, Abdullah Afif Siregar, Nizam Zikri Akbar, Tengku Winda Ardini, Cut Aryfa Andra, Anggia Chairuddin Lubis, Relationship Between Neutrophil-Lymphocyte Ratio Value And Severity of Mitral Stenosis Due to Rheumatic Heart Disease in Outpatients at H. Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 3 No. 12 (2024): December
- Fitriend Syahputri, Imam Budi Putra, Nelva K. Jusuf, Relationship between Plasma Fibronectin Levels and Stretch Marks , Journal of Society Medicine: Vol. 3 No. 4 (2024): April
- Abdurrahman Asysyarif, Elvita Rahmi Daulay, Kiking Ritarwan, Correlation of Lacunar Infarct on Head Ct Scan with Dysarthria in Haji Adam Malik General Hospital in 2019 , Journal of Society Medicine: Vol. 2 No. 1 (2023): January
You may also start an advanced similarity search for this article.